Announced this week, the trial will be run by an international consortium led by Aga Khan University and comprising the National Institute of Health in Pakistan; University of Oxford; the International Vaccine Institute and Harvard Medical School. The Coalition for Epidemic Preparedness Innovations (CEPI) will provide up to $11.7m of funding for the project.
Heterologous combinations of COVID-19 vaccines could help with supply, plugging a gap if a certain vaccine is not available and allowing vaccination campaigns to continue seamlessly. It could also potentially increase vaccine efficacy, particularly if a second vaccine type is more effective against an emerging variant.
Pakistan trial: AstraZeneca, Sinopharm and CanSinoBIO
In Pakistan, the clinical trial will assess the safety and immunogenicity of mix-and-match combinations of three vaccines that are currently available in Pakistan: developed by AstraZeneca, Sinopharm and CanSinoBIO.
“Data on mix-and-match combinations of these vaccines, which are commonly used in low- and middle-income countries (LMICs), are urgently needed to contribute to the design of more flexible vaccination strategies and mitigate against shortages of vaccine at times of uncertain or fluctuating supplies,” notes CEPI.
“The trial will also generate valuable data on the immune response after vaccination to the different variants circulating in Pakistan. All of the data will be made available open source to inform policy makers and regulatory authorities’ recommendations on the use of COVID-19 vaccines.”
Mix-and-match COVID-19 vaccines: New trial to add to research - BioPharma-Reporter.com
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